Twenty-eight weeks after the spread of a deadly rage virus, the inhabitants of the British Isles have lost their battle against the onslaught, as the virus has killed everyone there. Six months later, a group of Americans dare to set foot on the Isles, convinced the danger has passed. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.

At a school reunion dinner in a remote country mansion, a dozen people are offered the chance to collect a million pounds each if they can stay on the estate, cut off from the outside world, for 96 hours.

Deep in the countryside, near a dilapidated mobile home, a small boy is playing while a man is beating his mother. Yet, because this is the only family he has, the boy tries to make the man stay by offering him the only present he can give.