In the old city of Taranto, an industrial center of the Apulia region, Maria tries to help her junkie brother Donato, who is threatened with death for an unpaid debt. She only has one option: to steal. As much as possible, as soon as possible.

1963. The young nurse Anna begins working in the juvenile ward of a mental hospital. There she meets Lucia, a fifteen-year-old schizophrenic. Against the backdrop of a struggle between Dr. Marie and the rigid Dr. Oreste to reform patient treatment, a relationship between Anna and Lucia develops, forcing them to make decisive choices for their respective lives.

A unique portrayal of two young amateur actresses embarking on a journey that will forever change their lives as they star in the most eagerly anticipated new show of 2018, Elena Ferrante's My Brilliant Friend.