Penelope, better known as Polka-Dot, is a spunky young girl who has a knack for helping people, particularly her ailing mother. While out looking for a part-time job, Polka-Dot befriends a hard-nosed police officer and his tracking dog, Luey. When Polka-Dot's mother's condition worsens, Luey helps Polka-Dot find the strength and faith inside to help her move forward.

This deliriously offensive, gory horror-comedy features an underground comic book artist whose obscene caricature upsets a crime lord, who responds by cutting off the young man’s hand. The young man wallows in post-severed hand depression. Will criminality reign supreme? Will he live alone as a bitter one-handed man? Not if the slightly rotted hand, now alive and determined to exact revenge, teems up with his former body and a masked S&M gay superhero to rid the city of evil.

A last stop for gas before entering America's desert wasteland turns a family dream vacation into a small town nightmare for a teenage girl and her parents as they all become victims of a human trafficking ring.