Stéphane, Cathy and Thierry are the best employees of the Employment Agency of their city. But their results are so good that the agency will have to close because of a lack of unemployed. The three colleagues then have the crazy idea of creating unemployment to save their job.

Roxana Orlac, a famous violinist, loses the use of her hands in a terrible lift accident. Her career as a virtuoso seems to be over until Professor Christansen offers her a transplant of two new hands. What he omits to tell her is that the two hands in question belonged to a woman who murdered her own children. When unexplained incidents happen, followed by a murder in Roxana's entourage, she starts to wonder whether her new hands may be committing crimes of which she's unaware. Police Capitain Almeida, in charge of the investigation, falls in love with Roxana, but she remains the prime suspect. Is it possible that Roxana's hands are urging Roxana to do terrible things she's not even conscious of? Or is she the victim of some terrible plot?

Antoine, a bachelor party-goer, gets new roommates: Jeanne and her two children.

Daphné, who cut off contact with her family 20 years ago, decides to come back and see her mother, Claudine. She fears the reunion and hope Claudine will put up with who she is now.