The titular Marie-Louise is a young French lass who is evacuated to Switzerland when her country is overrun by the Nazis. Suffering a nervous breakdown, she is given comfort and shelter by a wealthy family. Unfortunately, living in the lap of luxury makes Marie-Louise hesitant to return home to her mother and war torn home. Eventually the girl comes to her senses, but it isn't easy.

Heidi, a young orphan girl living with her aunt in Frankfurt, is forced to move to the Swiss Alps to live with her ornery grandfather. At first, he resents her presence, but, after a short while, Heidi manages to pierce his gruff exterior, and the two become close. She also befriends a young shepherd named Peter. After three years, Heidi's aunt arrives and demands Heidi's return to Frankfurt.

If any one man is responsible for the rejuvenation of the postwar Swiss film industry, that man was director Leopold Lindtberg. Matto Regiert (Madness Rules) was co-adapted for the screen by Lindtberg from a novel by Friedrich Glauser. Heinrich Gretler stars as Police Constable Studer, the hero of several of Glauser's most popular works. This time, Studer must solve the murder of the director of an insane asylum -- and it's not (surprise, surprise) the most likely suspect, manic-depressive patient Herbert Caplaun. For box-office purposes, Matto Regiert stresses a romantic subplot involving Caplaun and nurse Irma Wasem.

Realist melodrama set in Zurich. In the old town district, people are concerned about Mäni, the child of a toilet attendant, who is growing up without a father. Postman Jucker appeals to the boy's conscience and protects him from unjustified accusations. After Mäni's mother dies, Jucker, who has become the child's guardian, takes Mäni into his home. Mrs. Jucker does not accept the boy and accuses Jucker of forgetting their own deceased child. Mrs. Jucker flees to her sister's house. Mäni also runs away.

While on a longer business trip, a wannabe poet urges his beautiful but more simple wife to answer his overly swollen love letters. With no idea how to respond she forwards the letters to a new young school teacher to use his answers instead...