While the sport of boxing requires sacrifice, discipline, concentration, and determination for Manny Pacquiao, it was survival.

Oscar De La Hoya vs. Manny Pacquiao, also billed as The Dream Match, was a professional boxing welterweight superfight. The bout took place on December 6, 2008 at the MGM Grand Garden Arena, Las Vegas, Nevada, United States.

From abject poverty to becoming a ten-time boxing world champion, congressman, and international icon, Manny Pacquiao is the true definition of a Cinderella story. In the Philippines, he first entered the ring as a sixteen-year-old weighing ninety-eight pounds with the goal of earning money to feed his family. Now, almost twenty years later, when he fights, the country of 100 million people comes to a complete standstill to watch. Regarded for his ability to bring people together, Pacquiao entered the political arena in 2010. As history’s first boxing congressman, Pacquiao now fights for his people both inside and outside of the ring. Now at the height of his career, he is faced with maneuvering an unscrupulous sport while maintaining his political duties. The question now is, what bridge is too far for Manny Pacquiao to cross?

Dubbed as the “Grand Finale”, Pacquiao vs. Morales 3 will be the deciding match for this great rivalry. This rivalry could easily be one of the best rivalries in boxing history and is likened to the Barrera-Morales and Gatti-Ward rivalries. Pacquiao vs. Morales III will take place at the Thomas & Mack Center in Las Vegas on November 18, 2006.

When Manny Pacquiao fought Jorge Solis on April 14, 2007 at the Alamodome in San Antonio, Texas, his star had already risen. Pacman already had his first fight with Marco Antonio Barerra, his three fights with Erik Morales, and his first of four fights with Juan Manuel Marquez. But Solis was undefeated at 33-0-2, and the general consensus was that Pacquiao, while a force of nature, couldn’t go on forever

Manny Pacquiao vs. Miguel Cotto, billed as Firepower, was a boxing match for the WBO welterweight championship. The bout was held on November 14, 2009, at the MGM Grand Garden Arena, in Las Vegas, Nevada, United States. The fight was sanctioned as a world title fight in the welterweight division, where the weight limit is 147 pounds, however Cotto's camp agreed to fight at a catchweight of 145 pounds to accommodate Pacquiao's smaller physique. Cotto's camp also conceded the larger share of the purse to Pacquiao, who received a 65% share of pay-per-view buys, compared to Cotto's 35% share.

Three-division world champion MARCO ANTONIO BARRERA, has declared war on his opponent and nemesis, pound for pound superstar Manny Pacquiao. Barrera, who began his fifth week of secluded high altitude training in Mexico, is preparing to battle and dethrone the reigning "Fighter of the Year" in a 12-round super featherweight boxing rumble 2. Marco Antonio Barrera will fight Manny Pacquiao on October 6th at Mandalay Bay in Las Vegas, Nevada.

In May 2004, Márquez fought Lineal & The Ring Featherweight Champion Manny Pacquiao in a bout where Márquez was knocked down three times in the 1st round. Marquez outboxed Pacquiao for the remainder of the bout which was ended in a controversial, split-decision draw. The final scores were 115–110 for Márquez, 115–110 for Pacquiao and 113–113. Judge Burt A. Clements (who scored the bout 113–113) later admitted to making an error on the scorecards, because he had scored the first round as 10–7 in favor of Pacquiao instead of the standard 10–6 for a three-knockdown round

Manny Pacquiao vs. Joshua Clottey, billed as The Event, was a welterweight fight for the WBO World welterweight championship. The bout was held on March 13, 2010, at Cowboys Stadium, in Arlington, Texas, United States. This match was put together after the long awaited "superfight" between Manny Pacquiao and Floyd Mayweather, Jr. had fallen through.

The rematch between Manny Pacquiao and Juan Manuel Marquez took place at Mandalay Bay, Las Vegas on March 15, 2008. These two men laced up for an unbelievable show down.