Kamay ni Satanas tells of Ka Berto, an aged “albularyo” or folk healer, who has a great love for Senyang, a young pretty lass, the daughter of his good friend. Fearing that he has no chance at all, he sells his right hand to the devil in exchange for youth, good looks, and wealth.

This movie captures the core and colorful saga of the famous Ilocano hero Diego Silang.