Deserted by her husband, John Madison, because he incorrectly accuses her of having an affair, Mary Madison goes to her aunt's house to have her baby, and then loses her memory in a train wreck. John, however, hears that she has died, so he takes possession of their infant daughter.

The film opens in Ireland, as a dying Patrick McNairne tells his daughter Jerry to go to New York and look up Norton Burbeck, a wealthy young man whose life Patrick had saved some time earlier (the surviving print, largely complete, lacks the second page insert of a letter explaining the full background). The affable Burbeck is due to inherit his uncle’s fortune provided he’s married by November; if not, the inheritance will go to his cousin Howard Curtis. An adventuress, Beatrice Gaden, and her husband Dick are in cahoots with Curtis: Beatrice pretends to be single in order to string Norton along up to the November date, at which time Curtis will come into the money and give a share to his unscrupulous partners.

When Edith Graham returns from school to live with her father, Lieutenant Graham, at a Northwest Mounted Police post in Hudson's Bay, she finds herself courted by two suitors, Corporal John Emerson and Reginald Annesley, the latter of whom is a wealthy purchasing agent for the post. Annesley however is also involved with the half-breed Marie. When Marie tells him she is carrying his child Annesley kills her and attempts to frame Emerson. However, Edith is suspicious and sets out to find the truth.

Corporal Blake is sent to apprehend the murderer of François Breault. All evidence points to Jan Thoreau as the guilty man. Blake arrives at Thoreau's cabin while he is away and is greeted by his wife Marie. Posing as a friend of her husband, Blake learns that Thoreau and Breault had quarreled shortly before the murder. This, together with Breault's dying accusation that Thoreau was his murderer, seems undeniable evidence. Blake, fascinated by Marie, agrees to let Thoreau escape, providing that she become his mistress. After much anguish, she consents. When Thoreau arrives, Blake arrests him but during the night Marie helps him escape. Blake goes in pursuit.

George Crosby, a New York lawyer, with a passion for painting, wearied of his legal duties, sails for Brittany, where he meets Renée Kerouac, a fisher-maiden, and sketches her as a Corregan, a fairy who destroys the men who refuse her love. Hoel Kalloc, her betrothed, becomes jealous, and George marries her, after saving her from Hoel's brutality.

Queen of the Moulin Rouge is a 1922 American silent drama film directed by Ray C. Smallwood and starring Martha Mansfield, Joseph Striker and Jane Thomas.

Krishna Dhwaj, the son of the Maharajah of Rhamput, is in love with Lakshima, the daughter of the Maharajah of Bhartari, but their fathers will not allow them to marry. Krishna is then sent to Harvard to get an American education. Lakshima, determined to kill herself when her father orders her to marry an old man, jumps into the ocean. She does not drown, however, but is rescued by George Morling, a Bostonian, who smuggles her on board his ship dressed in boy's clothing. George, the son of a minister, is engaged to a proper Bostonian woman. Although he has not behaved improperly, George fears that his fiancé and her father will not understand the situation, and so he hides Lakshima in a trunk. Once back in Boston, George's fiancé discovers Lakshima and is horrified, but after several misunderstandings, George and his fiancé are reconciled, and Lakshima is able to find and marry her Indian sweetheart Krishna.