Dr. Eric Vornoff, with the help of his mute assistant Lobo, captures twelve men for a grisly experiment; His goal to turn them into supermen using atomic energy. Reporter Janet Lawton, fiancée of the local lieutenant, vows to investigate Vornoff's supposedly haunted house.

In North Carolina, Daniel Boone hears amazing tales about Kentucky and decides to move his family there. But first he has to find the Indian path that will lead him and earn enough money trapping to repay a loan. The Indians are not happy that settlers are coming, and make life difficult for them.