In a post-apocalyptic world inspired by New Orleans, the tragic love of Orpheus and Eurydice is intertwined with the complex relationship of Hades and Persephone. Eurydice, struggling with poverty, is lured to the industrial underworld of Hadestown by Hades, while Orpheus, a struggling musician, ventures down below to bring her back.

When Harper and her daughter take the law into their own hands, they believe they have the upper hand. But their plans take a dark turn when they kidnap the drunk driver that killed Harper's husband and he isn't what he seems.