On an idyllic Caribbean island, Panama Sugar and his friends, engage a battle with Fox Perry, the wealthy American boss who would like to purchase the island to make a Las Vegas exotic.

In the late 1970s and early 80s, assassinations in Sicily get the attention of Communist deputy, Pio La Torre, who appeals to General Carlo Alberto Dalla Chiesa to become prefect in Palermo and take on the Mafia. Dalla Chiesa approaches the job with the same focus and methods he used in hunting down the Red Brigade.