On the anniversary of a tragic accident, four adults reunite for a weekend by the lake. Slipping into the familiarities of their close past, home comforts soon turn to hidden truths. As the secrets ripple out, the siblings, friends and lovers are pushed to face each other like never before in a night that promises to change them forever.

Soon after moving in with her aging aunt Dora, Adele meets Beth, seductive and mysterious, who tests the limits of Adele's moral ground and sends her spiraling down a psychologically unstable and phantasmagoric path.

Hilarious and outgoing, Brittany Forgler, is everybody’s best friend ― except her own. Her partying, underemployment and toxic relationships are catching up with her. She receives a startling wake-up call when a visit to the doctor reveals how unhealthy she is. Motivated to lose weight, but too broke for a gym and too proud to ask for help, Brit is at a loss, until her neighbor pushes her to run one sweaty block. Soon, she sets an almost unthinkable goal: the New York City Marathon.

A mother of three daughters (one died at the age of three) commits a crime of conscience and becomes radicalized in prison; she turns into an idealist run amok, determined to change her little corner of the world for the better. Her middle daughter, with a physician for a father, an older sister who joins Doctors Without Borders, and a baby sister who dies, is fanatically trying to find a place for herself in this family of overachievers.