Entirely made in California, the film brings together 30 American and European actors in an epic which crosses the mythical territories of that cinematic land from Zabriskie Point to Mulholland Drive. California is revisited through the movie memories incarnated by the very presence of famous actors and actresses. "The American Tetralogy" is a way of staging reality which questions the fictional nature of the movies.

This fictionalized story, based on the family life of writer James Jones, is an emotional slice-of-life story. Jones is portrayed here as Bill Willis, a former war hero turned author who combats alcoholism and is starting to experience health problems. Living in France with his wife, daughter, and an adopted son, the family travels an unconventional road which casts them as outsiders to others. Preaching a sexual freedom, his daughter's sexual discovery begins at an early age and betrays her when the family moves to Hanover in America. Her overt sexuality clashes with the values of her teenage American peers and gives her a problematic reputation. Meanwhile, her brooding brother copes with his own interior pain regarding his past, only comfortable communicating within the domestic space.

A couple argue about whether or not they should have a baby.