Although Kenneth Carmont and Esther Saunders, criminal Bert Saunders' sister, love each other, Esther marries detective Elwood Collins, who agrees to stop pursuing Bert if she accepts his proposal. One night, Kenneth and Esther hide Bert, who has escaped from the police. The same night, Kenneth's father is murdered. The evidence implicates Kenneth, who cannot supply his whereabouts at the time of the crime, as that would give away Bert. Esther cannot clear Kenneth for the same reason, and because it would let her husband know that she was with her former sweetheart.

Widower Calvert Paige leaves his baby daughter Johnnie in New York and goes West where he becomes wealthy as a mine owner and newspaperman. Lil Magill, who came to work on his newspaper, becomes infatuated with Paige, as he is with her, and they become lovers. After several years Lil has become a successful author but Paige has tired of her. Their estrangement grows when Lil takes the side of striking miners against him.

When 9-year-old orphan Oliver Twist dares to ask his cruel taskmaster, Mr. Bumble, for a second serving of gruel, he's hired out as an apprentice. Escaping that dismal fate, young Oliver falls in with the street urchin known as the Artful Dodger and his criminal mentor, Fagin. When kindly Mr. Brownlow takes Oliver in, Fagin's evil henchman Bill Sikes plots to kidnap the boy.

Dr. Dudley Duprez is a well-known Louisiana physician. His beautiful but wayward niece, Rose Duprez, is abducted by Paul Crenshaw, a friend of the doctor, and to prevent her shame from becoming known, Rose kills herself. Dr. Duprez learns her secret and determines to make Crenshaw expiate his crime. While traveling on a Mississippi River steamer, the doctor wins Mercedes, a beautiful slave, at cards. He takes her home and, passing her off as a distant relative, arranges it so that Crenshaw falls in love with the girl.

Molly is a young woman who out of desperation after failing to find work steals a pocketbook from a society woman, Blanche Armstrong. This act leads her into a legal conflict involving the District Attorney, Roger Hackett, who uses the situation to pursue his own lustful interests.