Luì is about to receive his diploma as a scientist until Mr. S and Perfidia will try to undermine the Me against You.

The story very freely echoes the vicissitudes of an expedition that really took place in the 19th century in the harsh and wild lands of the West.

A young couple who makes popular YouTube videos for children sets out to win an award, but an evil mastermind stands in the way of their success.

A beautiful school is about to reopen after many years and Luì and Sofì (Me against You) are the special guests of the inauguration party, their friend Pongo awaits them there. The school, however, could hide a mystery and, once again, the Me against You will have to face the evil Mr. S with courage and try to sabotage his evil plans in the name of friendship. In the school, for the first time, Luì and Sofì could learn an important secret about their past. A new “magical” adventure in the cinema for Luì and Sofì, in a world of magic, with lots of surprises and fun for their little fans and all families.

The alliance of Malefics, formed by Mr. S., Perfidia, Viperiana and Serpe have convinced the world that He and Sophi are criminals and the two, in order not to be wanted, join other characters to prove their innocence and bring harmony back to the planet.