In 1984-85, people at Lake Tahoe fell ill with flu symptoms, but they didn't get better. Medical literature documents similar outbreaks: in 1934 at LA county hospital, in 1948-49 in Iceland, in 1956 in Punta Gorda, Florida. The malady now has a name, chronic fatigue syndrome, and filmmaker Kim Snyder, who suffered from the disease for several years, tells her story and talks to victims and their families, and to physicians and researchers: is it viral, it is psychosomatic, is it one disease or several (a syndrome) ; what's the CDC doing about it; what's it like to have a disease that's not yet understood? Her inquiry takes her to Punta Gorda and to a high-school graduation.

Sam is transferring between two airports during his stopover in London, carrying a big suitcase with a broken handle. While waiting for his bus in the city center, he wanders away from the bus terminal in search for a toilet. During this night odyssey it soon becomes apparent that that trust is hard to find, and that things seldom are what they appear to be.