Fujiko Mine, the devastating femme fatale whose only loyalty is to her desire, befriends a young boy whose late father hid away a fortune. A killer is on the boy's trail and it's up to Fujiko to stop him: but where do her interests really lie?

Mirai and Liko come to the human world to play, but are separated when the witch Sorcierre and her servant Trauuma suddenly appear. Their aim is to acquire the tears of the 44 Pretty Cures, using them for her Most Evil Magic. Only the friendship of all 44 Pretty Cures will allow them to protect the world.