The Angry Guest is a direct sequel to Duel of Fists which had two long-separated brothers, Ti Lung and David Chiang, reuniting in Bangkok and running afoul of the local mob after Ti Lung, a boxer, beats the local favorite in the ring. In this film, the action shifts from Bangkok to Hong Kong to Japan and then back to HK as the brothers contend with a Japanese mob led by crime boss Yamaguchi, who is played by the film's director, Chang Cheh, in a rare screen appearance.

Lawman Gong Tianlong captures vicious thief and murderer Guan Yunfei but an ambush by hired men sees the thief set free and Tianlong's whole family murdered. Left to die himself but rescued by Ling Tzu, Yunfei's son frames Tianlong's and throws him away to rot in jail. All while Yunfei betrays an accomplice of his but ends up blind in the ensuing fight. Cut to 15 years later with Tianlong desiring revenge, Yunfei has developed into a skilled, blind swordsman and into the two's rivalry enters innocent family...