In Knockemstiff, Ohio and its neighboring backwoods, sinister characters converge around young Arvin Russell as he fights the evil forces that threaten him and his family.

Two rival politicians compete to win an election to represent their small North Carolina congressional district in the United States House of Representatives.

When new parents Alex and Penny retreat from the city and move into a place outside town, the stress and massive sleep-deprivation caused by their infant has both of them seeing things in the house that may or may not exist. Persistent sightings of a strange woman has each of them wondering if they are suffering from hallucinations, or if their new home holds a dark, supernatural presence. As their fragile grasp on reality spirals into delirium, Alex and Penny find themselves nearly helpless to deal with the horrific truth of what is really going in this house.