After their father passes away, three siblings reconnect at their mother's remarriage.

TUFO tells the story of the Cutrò family and their resistence agianst the mafia as witnesses of justice.

Based on the real story of Fulvio Frisone, born with spastic quadriplegia dystonia severe enough to prevent him from even speaking. Thanks largely to the enormous efforts of the mother Lucia, Fulvio, apparently condemned to a life without opportunities, manage to study with great profit, and today is an accomplished scientist in the field of Physics.

Mauro is 33 years old and has two graduate degrees, but lives with his parents and can't find a job to save his life...or his sanity. As Mauro begins to inexplicably go off the deep end, he begins self-sabotaging his dates and his job interviews, terrorizing the family maid and making his mother and father wonder what they did to deserve a son like this. Will poor Mauro ever regain his sanity?

Forced to come back to Palermo to take care of his elderly parents, a deadpan driver-for-hire takes advantage of the situation to get back at the rigid authority figures who ruined his teenage years.