A young woman who works as a secretary is raped, and unjustly accused of drug trafficking, a corrupt system finds her guilty and makes her pay a long prison sentence.The Panther of the Border seeks revenge against a ruthless drug cartel.

The lives of two young families who lived in the same house, starts turning upside down when they find the amulet that La Llorona uses to try to pull her children from the waters and bring them to life. While the authorities investigate what appears to be abused children, the spirit of La Llorona intensifies her attacks on those families.

A story full of love, friendship and faith, which shows that despite the circumstances of life there is always hope. El Mugrosito del Barrio is a boy who suffers when he learns that his mother suffers from cancer and loses the battle against the disease, his grandmother takes care of him and they survive in misery, until his grandmother also dies due to a misfortune of life.

A family involved in illegal business dealings begins to be executed by a mysterious killer. A deaf man approaches them to help them. And many suspects arise from the disappearances. The family starts to fall apart by the killer but no where to be found.