With the occasion all but overshadowed by her sister's upcoming wedding, angst-ridden Samantha faces her 16th birthday with typical adolescent dread. Samantha pines for studly older boy Jake, but worries that her chastity will be a turnoff for the popular senior. Meanwhile, she must constantly rebuff the affections of nerdy Ted, who is unfortunately the only boy in school who seems to take an interest in her.

Oliver can't help but wonder if his new tattoo is the cause of his recent spate of romantic bad luck. Gay and single in San Francisco, he spends a lot of time out and about meeting other like individuals. As he fails repeatedly to connect with any eligible bachelors and it seems that the pickings are getting slimmer and slimmer, he becomes more and more distraught over what could be the true meaning and power of his tattoo and whether it has doomed him to be alone forever.

Jack Farley and his family are asked to attend an experiment about social behavior for a planned space station. Therefore they move into an underground dome for three months. But then it turns out that a secret military department replaced the NASA scientists and conducts an experiment on its own...