Four sisters come of age in America in the aftermath of the Civil War.

In 1839, the slave ship Amistad set sail from Cuba to America. During the long trip, Cinque leads the slaves in an unprecedented uprising. They are then held prisoner in Connecticut, and their release becomes the subject of heated debate. Freed slave Theodore Joadson wants Cinque and the others exonerated and recruits property lawyer Roger Baldwin to help his case. Eventually, John Quincy Adams also becomes an ally.

A British Revolutionary War drummer accidentally deserts from his regiment and is hunted down for execution.

In 1983, yacht sailor Will Parker leads an American crew financed by millionaire Morgan Weld to defeat during the America's Cup race against an Australian crew. Determined to get the prize back, Will convinces Morgan to finance an experimental boat designed by his ex-girlfriend Kate's new beau, Joe Heisler. When the boat is completed, the Americans head to Australia to reclaim the cup.

Katherine Watson is a recent UCLA graduate hired to teach art history at the prestigious all-female Wellesley College, in 1953. Determined to confront the outdated mores of society and the institution that embraces them, Katherine inspires her traditional students, including Betty and Joan, to challenge the lives they are expected to lead.

The administrator of a medical company is forced to match wits with a serial killer, who targets people who commit insurance fraud with the State's Medicaid system.

To take down South Boston's Irish Mafia, the police send in one of their own to infiltrate the underworld, not realizing the syndicate has done likewise. While an undercover cop curries favor with the mob kingpin, a career criminal rises through the police ranks. But both sides soon discover there's a mole among them.

Homer is an orphan who was never adopted, becoming the favorite of orphanage director Dr. Larch. Dr. Larch imparts his full medical knowledge on Homer, who becomes a skilled, albeit unlicensed, physician. But Homer yearns for a self-chosen life outside the orphanage. What will Homer learn about life and love in the cider house? What of the destiny that Dr. Larch has planned for him?

Three converging story lines involving bootleggers, a serial killer and drug dealers are followed. A former drug dealer tries to go straight, but comes across a stash of stolen drugs. Meanwhile, a middle-aged suburban housewife hides a sadistic and vicious streak.

After her return from school in Paris, a playboy finally takes notice of his family's chauffeur's daughter Sabrina, who's long had a crush on him, but he questions his more serious brother's motives when he warns against getting involved with her.