Take a Chance was based on the hit Broadway musical of the same name, though only one of the original songs, Eadie Was a Lady, has been retained. The thinnish plot involves the misadventures of a pair of pickpockets, played on Broadway by Jack Haley and Sid Silvers and on film by James Dunn and Cliff “Ukelele Ike” Edwards.

A blacksmith's son from Naples rises to become a celebrated opera singer, performing at La Scala in Milan.

A group of air mail pilots risk their lives to deliver important mail through bad weather conditions.

In France, opera star Enrico Baroni is tired of his mistress Pompom. After a performance, Enrico goes to a cabaret with his manager, Muldoni, and some friends. When Pompom arrives, Enrico leaves the cabaret with his servant, Fresco. Hearing music nearby, Enrico and Fresco discover a band of gypsies.