Zona Zamfirova is set in the eastern Serbian city of Niš in the 19th century. The plot follows the story of Zona Zamfirova, a local rich man's daughter, and the vicissitudes of her affair with Mane, an ordinary goldsmith. As it was undesirable for the daughter of a rich man to marry a craftsman, the two are at first divided, with the possibility of Zona marrying Manulać, who came from a wealthy family. Everything is, however, changed as Mane organizes a successful conspiracy to keep Zona for himself.

The plot revolves around a wedding party from Pavlikeni, a town in Bulgaria, heading to Sofia. The leader, Karaatanov, convinces the theater director to allow the party to stay during a performance, leading to a series of chaotic events.