Five down-on-their luck strangers meet by chance while looking at a property in the country none of them are able to afford. They decide to join forces and risk everything to turn it into a B&B, only for the local mafia to show up demanding their "fair" share.

It’s Ferragosto, Italy’s mid-August holiday, in a practically deserted hospital in Naples. Two nurses, Angelo and Salvatore, are on shift when a desperately ill patient is wheeled in. With his seasoned eye, Angelo knows at once that Mr. Caputo won’t last the night. Salvatore happens to loathe Angelo and decides to bet on the opposite outcome. The winner of the bet will nab the top holiday slot: Christmas vacation. Angelo takes up the challenge. From that moment on, Salvatore will spend the night trying to keep Mr. Caputo alive, while Angelo will play dirty to make sure he wins the bet. That night, it’s anything goes at their hospital, from the nurses’ cheap shots to doctors on cocaine and suspicious characters lurking in the ward.

A Mafia boss fakes his own death aiming at a fresh start, but a nurse happens to see him alive and well after the funeral. A hitman is promptly sent to get rid of her, only to find out she's his first and unforgotten love.