In this award-winning sequel, the Gangsters are living well one year later. Jack, Sam, and Tobin run across a dying man who informs them of a psychopath holding people hostage in a town nearby. When he mentions Max Castelli is one of the prisoners, the Gangsters give their undivided attention to this new villain in hopes of rescuing a family member they thought had died with the plague.

Our Gangsters are captured by scientists who began this epic adventure. Hooking up with one of their own, they must fight for their lives to save the child who holds the answer. Knowing the fate of humanity lies in the balance, how will they overcome?