A middle-class Italian family is tore apart when the father meets an old flame, the mother—a frustrated onetime actress—auditions for a play, their insecure son tries to make friends through drugs, and their underaged daughter—who has already figured out how to use sex to her advantage—does what she does best to appear on TV.

Arrogant, self-centered movie director Guido Contini finds himself struggling to find meaning, purpose, and a script for his latest film endeavor. With only a week left before shooting begins, he desperately searches for answers and inspiration from his wife, his mistress, his muse, and his mother.