Mario and Veronica, a married couple with no children, are both very committed to their careers, which are booming. He's a sales representative for a fertilizer company, while she inherited a boutique from her mother that she wants to renovate and transform. However, things take an unexpected turn when she discovers she's pregnant. What should be good news backfires, as he, almost at the same time, receives test results declaring him sterile.

Two wealthy Roman sisters, Marina and Sabrina, the first betrayed wife of a homosexual surgeon, the second left by her multi-horned husband, escape from their respective failures and take a vacation at Circeo, in a splendid villa by the sea. With them there is also Lorena, Marina's masseuse, who has also returned from a sentimental disappointment, and after a few days they are joined by Caterina, the third sister, costume designer for the cinema. She decided each of her in her own way to solve her problems with men, they will end up victims of a seducer and scoundrel writer, but they will always know how to get back on their feet.

Three girls leave behind their camping friends and head to Porto Cervo - a luxury seaside resort in northern Sardinia - looking for adventure.