Innocent women are being kidnapped and used as guinea pigs for a brain transplant experiment. The diabolical Dr. Frankenstein continues his quest to perfect his brain transplant operation to bring back his deceased wife at any cost - even if it means playing with the lives of others. El Santo and Blue Demon are called in to help when their friend Alicia becomes Dr. Frankenstein's next target. It'll take both heroes to go up against the dastardly doctor and go mano a mano with his super strong zombie Golem.

Dr. Frankenstein and her assistant, Dr. Yanco, are going to bring one of their experiments to life in Santo Vs. Frankenstein's Daughter. She intends to use a monster named Ursus to do her evil bidding. Using a youth serum to retain their vitality, the doctors set their sights upon none other than El Santo. They need his super human blood to regenerate a stronger youth serum. They kidnap Santo's goddaughter, Norma and lure him into Dr. Frankenstein's lab where he is captured and enslaved. Will Santo make it out alive?

A group of international criminals steal a large emerald from a heavily guarded Colombian mine and they plan to sell it on the black market. Unfortunately, the evil Dr. Igor is also manipulating other criminals, as well as the ones who stole the emerald, for his own benefit. Santo, a Mexican wrestler/Interpol agent works with the Colombian authorities in an attempt to recover the emerald and to stop Dr. Igor and his subordinates, as well.

A professor recruits a professional wrestler to protect his daughter from vampires intent on kidnapping her and marrying her to the devil.

Tourists visiting the pyramids in Mexico experience a string of deaths and disappearances while staying at a nearby hotel. Police investigators Fernando and Cornado are assigned to the case and attempt to solve the mystery with the help of reporter (and girlfriend of Fernando) Veronica and the wrestler Santo.

Santo and Blue Demon take on a 300-year-old witch with a nasty attitude. She raises a legion of zombies and sends them to fight Santo in his home and in the rings.

Bruno Halder a sinister scientist seeking revenge against his brother and niece is resurrected by Waldo his faithful sidekick. Besides his minions of zombies Halder enlists the help of Wolfman, Franquestain, a Vampire, a Mummy and a Cyclops. Once again the survival of mankind is put in the hands of Santo

Agent Joaquin recalls his latest mission while lying wounded in an ambulance: Joaquin has infiltrated into a band of smugglers. When the villains learn the truth about him, they kidnap Jouqin's fiancee. Santo comes to her rescue and fights the band.

El Santo, the masked Mexican wrestler, investigates a series of kidnappings. He discovers that the mysterious Doctor Caroll is using the victims as part of his experiments to develop an army of monsters. Naturally, El Santo is able to overcome them all - with wrestling!

In the Age of the Inquisitions, 1603, Santo, El Enmascarado de Plata, is being laid to rest by a group of monks. The Black Hood, an axe-wielder and a tormented soul who sold his soul to the devil after losing his love to El Santo, appears at the foot of his tomb and swears to seek his revenge no matter how many centuries it takes. El Santo is the chosen one and is sworn to fight for good and justice at any cost. After he finds his love, Alicia, dead at the hands of the Black Hood, El Santo must trust his faith and use his strength in this battle of good vs. evil.