Santa is a beautiful and very humble young girl living in Chimalistac, a small and quiet spot south of the 1930's Mexico City. After Santa is cheated by arrogant soldier Marcelino, she's rejected by her family and friends and expelled of Chimalistac. Santa finds shelter in a whorehouse and becomes a cinic and bitter woman, mistreated by bullfighter "Jarameno" and silently loved by blind pianist Hipolito.

Young couple weather a marital crisis while older people who have already given up on life interfere from the sidelines.