After the death of a United States Senator, idealistic Jefferson Smith is appointed as his replacement in Washington. Soon, the naive and earnest new senator has to battle political corruption.

Gunslinger Annie Oakley romances fellow sharpshooter Frank Butler as they travel with Buffalo Bill's Wild West Show.

Juliet Forrest is convinced that the reported death of her father in a mountain car crash was no accident. Her father was a prominent cheese scientist working on a secret recipe. To prove it was murder, she enlists the services of private eye Rigby Reardon. He finds a slip of paper containing a list of people who are 'The Friends and Enemies of Carlotta'.

As a parting shot, fired reporter Ann Mitchell prints a fake letter from unemployed "John Doe," who threatens suicide in protest of social ills. The paper is forced to rehire Ann and hires John Willoughby to impersonate "Doe." Ann and her bosses cynically milk the story for all it's worth, until the made-up "John Doe" philosophy starts a whole political movement.

Alice, the only relatively normal member of the eccentric Sycamore family, falls in love with Tony Kirby, but his wealthy banker father and snobbish mother strongly disapprove of the match. When the Kirbys are invited to dinner to become better acquainted with their future in-laws, things don't turn out the way Alice had hoped.

The Wolves baseball team gets steamed when they find they've been inherited by one K.C. Higgins, a suspected "fathead" who intends to take an active interest in running the team. But K.C. turns outs to be a beautiful woman who really knows her baseball. Second baseman Dennis Ryan promptly falls in love. But his playboy roommate Eddie O'Brien has his own notions about how to treat the new lady owner and some unsavory gamblers have their own ideas about how to handle Eddie.

A Texas oil driller schemes to steal millions of dollars in oil.

Chicago cop Johnny Kelly, dissatisfied with his job and marriage, would like to run away with his stripper girlfriend Angel Face, but keeps getting cold feet. During one crowded night, Angel Face decides she's had enough vacillation, and crooked lawyer Biddel has an illegal mission for Johnny that could put him in a financial position to act. But other, conflicting schemes are also in progress...

Bold performer Tira works as dancing beauty and lion tamer at a fair. Out of an urgent financial need, she agrees to a risky new number: she'll put her head into the lion's mouth! With this attraction, the circus makes it to New York and Tira can pursue her dearest occupation — flirting with rich men and accepting expensive presents.

The director's son gives interesting anecdotes about Frank Capra's making of the 1938 hit comedy, "You Can't Take It With You."