Historical drama that recounts the period of Peruvian doctor Daniel Alcides Carrión during his research on smallpox in 1885. Famous for inoculating himself with the virus and developing his own medical history, the plot explores, through memory, the events that led Carrión to make this decision and the consequences it had on his life and that of his loved ones.

In an apocalyptic future, a young couple of survivors invade an abandoned house in search of shelter and supplies to continue their journey to the other side of the hills, where a stable and safe community of survivors is said to exist. However, they are both unaware that a violent hunter lives inside the house, along with a bloodthirsty creature.