Invicta FC 52: Machado vs. McCormack was a mixed martial arts event headlined by Valesca Machado defending her strawweight championship against Danni McCormack. Montserrat Rendon was scheduled to fight Alexa Conners, but Conners was forced to withdraw and was replaced by Maria Favela. Favela later withdrew from the fight and the bout was removed from the card. Ramona Pascual was scheduled to fight Amber Leibrock but Leibrock withdrew after signing with PFL and was replaced by Kaylee Vos. However, Pascual was then unable to compete and the bout was removed from the card.

Invicta FC 50 took place Wednesday, November 16, 2022 with 7 fights at Reelworks Denver in Denver, Colorado.