A crooked real estate manipulator sells worthless land on mortgage to flood refugees, then tries to profit by reselling the land to the state, committing murder in the process, as the Three Mesquiteers work to bring him and his gang to justice.

A heartthrob singer, Tony Paige, also known as "America's Boyfriend" decides to wed a Swedish actress. His manager doesn't want this because he is afraid of Tony losing female fans so he takes up a 300 hundred thousand dollar insurance policy if Tony does in fact wed. Tony soon meets a girl name June Delaney on a bus who doesn't swoon over him like other girls. He falls for her but doesn't know her true identity.

American federal agent Clark Stuart is on assignment in Santa Fe to draw up a trade agreement with the newly installed Mexican governor. Meanwhile, Walter Jamison leads a wagon train from Missouri, hoping to take advantage of the new agreement. Among Jamison's passenger are famed frontiersman Jim Bowie and a very youthful Kit Carson. The destinies of all these personalities intersect when villainous ex-governor DuPrey schemes to undermine the treaty and take over the New Mexico territory for his own vile purposes. Somewhere along the way, Davy Crockett joins the "good guys" in their efforts to thwart the despicable DuPrey.