When his home of New Eden is destroyed by a revitalized Brotherhood and its new Vamp leader, Martin finds himself alone in the badlands of America with only the distant memory of his mentor and legendary vampire hunter, Mister, to guide him.

Ace, a 12-year-old boy is new in middle school. His grandfather from Transylvania passes away at the ripe age of 99, and sends him his dog, Fang, to look after. Ace soon discovers that Fang is a vampire dog. Professor Warhol, a mad scientist and her bumbling assistant Frank, try to capture Fang to steal his DNA, in order to look young.