Goody Rickby has a child out of wedlock, but it dies when the father, Gillead Wingate, refuses to acknowledge the child or help the mother get medical aid. Wingate becomes one of the foremost figures in the witch hunts, and Goody plots her revenge with Dr. Nicholas, who is really the Devil.

Ted MacDonald and his father, Edmund, sail to the South Seas to treat a cholera epidemic among the natives. Upon their return to Long Island, New York, Edmund is diagnosed with the disease, requiring him and Ted to remain on his ship, with regular visits by a doctor. Socialite Lois Brooke takes it upon herself to board the vessel, and she is also placed under quarantine. Lois and Ted fall in love, and during an extended visit to her home, he is seduced by her life of endless parties and hot jazz. An avaricious interloper attempts to come between Ted and Lois, but Edmund persuades them to return to the ship and continue their charitable mission.