When Henry Boone hears his grandfather's stories of his youth as a pioneer and scout, he is gripped by the fires of romance and decides to hunt adventure. Boone finds himself in an airplane carrying a military message to a leader of a revolution in a South American country. He is arrested as a spy but escapes and saves the ruler's daughter from the revolutionaries.

While on a train trip, Mary Ryan runs into her old friend Jane Loomis. Mary was once a professional thief but is now reformed. Jane tells her that her uncle, Judge Loomis, has invited her to live with he and his family, but that she is planning to elope with her boyfriend instead. When the train arrives at the town where Judge Looms lives, Mary gets off and passes herself off as Jane. Complications ensue.

Bill Bronson is a likable young bank clerk, whose congenital thirst for liquor is kept under control until he joins his wife Mary at getting blotto at a company party. From there it is a downward spiral.

Nara, the daughter of a wealthy Russian killed by the Bolsheviki, flees to America and meets Adam Pine, a sculptor, who marvels at the beauty of her hands. Through him she meets Mrs. Vanessa Yates, a patroness of the arts, and Dr. Emlen Claveloux, who is completely absorbed in science. Connor Lee, a fake spiritualist, persuades her that she has a God-given power to cure ill people, and profits financially by her success in this work. This brings her into conflict with the physician, whom she loves, but her faith in the power of will and her beauty of character finally teach him that faith is at least an important adjunct to medicine.

Norma Harvey, a newspaperwoman who devotes much of her time to relieving the sufferings of slum children, still loves her childhood sweetheart, Craig Dunlap, a lawyer who tries to cover up his wife's kleptomania by bribing a witness at her trial. Dunlap, however, is exposed and disbarred. While working in the slums, Norma encounters him in a disreputable dive and takes him to her home along with little Mazie, a blind orphan.