Over one night in New York City, lives of disparate strangers intersect by fate and circumstance.

Manny tries to get his crack addict brother, Danny, to clean up.

The lives of diverse characters in each of New York City's five boroughs overlap.

Welcome to the front lines of AIDS activism, where the latest enemy raids are being run by a band of unlikely warriors: two drag queens, an HIV-positive man with tiny gemstones dotting his bald head, and his HIV-positive sister.