Eat This New York is the story of two best friends' struggle to open a restaurant in the food capital of the world. As Billy Phelps and John McCormick suffer through financial crisis, the loss of their chef, and a crumbling relationship, the filmmakers turn the camera on New York City's legendary restaurateurs who prove that dreams can come true. Billy and John's gamble to open a restaurant together takes shape on Division Street, a unique block in Brooklyn that separates the Satmar Jewish community of Williamsburg from the Latino neighborhood of the South Side. During the course of a year, they convert a former check-cashing shop located under the elevated train tracks of the J/M/Z subway lines into a retro speakeasy. But before the restaurant is fully built they come close to bankruptcy and almost call it quits on their friendship.

After her mother's death, mediocre chef Amanda Shelton is having trouble attracting customers to her family's restaurant. While shopping for ingredients, she is given a magical crab by mysterious Gene O'Reilly. Afterward, Amanda's dishes suddenly become excellent, inducing strong emotional reactions in everyone who eats them. Tom Bartlett, who is preparing to open his own eatery, tries her cooking and falls in love.

Ella Brennan is a household name in the restaurant industry. Known today as the inspirational matriarch of the rambling Brennan family of New Orleans and the force of nature behind first Brennan's and then Commander's Palace. Fired by her family at one point, she shouldered on. She was the creator of elaborate New Orleans breakfasts and jazz brunches and revolutionized creole cuisine. A pioneer of the modern American food movement, she pushed her chefs to the forefront helping to launch the celebrity chef phenomenon.

New Yorkers such as novelist Salman Rushdie, Yankees manager Joe Torre and hip-hop star Russell Simmons discuss how 9/11 altered their perception of the world.