In California, Maria has awful nightmares and visions of her sister who committed suicide one year ago. Her roommate Chris invites Maria to travel with her and her friends Tanya and Rose on vacation to her uncle's house in Saguaro, Arizona, to relax. When the group arrives in the house, they immediately go to a night-club to have fun and chase some local guys for sex; however, the evil El Charro is seeking Maria, killing her friends with his machete.

In this classic retro horror thriller, Sam, an aspiring writer, takes a job as a clerk in an L.A. inner city grocery market owned by the sinister Dr. Munoz, a former scientist who claims to have a rare skin condition.