Reverend Jesse Hampton has a bone to pick with the management of Club Harlem, a wildly popular nightspot where drinking and dancing are the rule. No old-fashioned prude, the Reverend tries to see the positive side of the juke joint activities, knowing that the jitterbuggers are basically decent kids who just need to blow off a little steam. But the preacher sees red when the club opens on the Sabbath, threatening to turn the good townsfolk into Sunday sinners. An upcoming dance contest seems destined to become a showdown between the powers of light and darkness.

An idealistic young man is torn between a sultry Chicago nightclub owner and a Scottish South Dakotan farmgirl.

Hardworking Minnie (Cora Green) marries "Dollar" Bill (Bud Harris) a shady gambler after her money and her attractive daughter, Sue (Izanetta Wilcois). Sue meanwhile, is in love with Bob (Carl Hough), an idealist fond of looking out over the skyline and saying "Harlem... there's so much to be done here--it's fairly screaming for leadership." When Bob decides to organize the community against local racketeers he little realizes would-be father-in-law Dollar Bill is one of them. Bill meanwhile has problems of his own: A vicious white mob from lower Manhattan is muscling in on his action, and bullets are about to fly.

Dramatic events in a Harlem apartment house center around Pa Wilkins, chosen by the Better Business League to replace their ousted, crooked leader Marshall...who wants revenge; and Pa's ward Jim Bracton, a two-timing Romeo whose affairs are coming to a crisis. And hanging around is Marshall's murderous junkie henchman, Lomax. Will it all end in someone's being killed?

A movie producer offers a nightclub singer a role in his latest film, but all he really wants to do is bed her. She knows, but accepts anyway. Meanwhile, a patron at the club gets a note saying that she'll soon get another note, and that she will be killed ten minutes after that.