The movie is set up like an awards show, where Oderus Urungus and Sleazy P. Martini reminisce with montages. They are the only two members of Gwar to make appearances, save a brief cameo by Balsac the Jaws of Death at the end, though some of the other Slave Pit Inc. employees are featured. The announcer at the awards show is played by Chris Bopst, who was the first person to play Balsac the Jaws of Death.

That's right scum, Gwar's manager Sleazy P. Martini is back with his own fudge-packed talk show. Join Sleazy and crew as they welcome a host of ridiculous guests who exist only to be destroyed. The fur really starts to fly with the arrival of GWAR and nut-chinned mystic scumdog Scroda Moon. All this and less awaits you in It's Sleazy!

Guided by his doctor (or is it voices in his head?), a young director is given a mission: to go to Texas to make an abstract roadmovie (“Unfocused film! Focus is repressed!”) about the Housecore Horror Festival of Film and Music, a festival that brings together cinema and extreme music.

GWAR, the bloodthirsty alien antiheroes, conduct a worldwide telethon to feed souls to the World Maggot, which will transport the members of GWAR off our miserable planet once it grows. GWAR's tele-casts attract the attention of GlomCo, the world's monopolistic entertainment giant. GlomCo attempts to bribe GWAR's manager, Sleazy P. Martini, into selling GWAR out to the mainstream of Sunday morning cartoons. GWAR's revenge on the sniveling executives at GlomCo uncovers a dastardly plot to homogenize all humanity by the evil doctor Skulhedface!

Representatives of the government, clergy, and healthcare communities have banded together to censor Gwar's activities in America. Their covert organization, the self-appointed "Morality Squad" has captured Gwar "member" The Cuttlefish of Cthulu and put it on trial for obscenity. Gwar ventures forth from their Antarctic stronghold to rescue their compatriot and unleashes untold horrors on America in the name of Freedom of Sexpression. This was Gwar's first commercially released long form video and was nominated for a Grammy in 1993.