Oh Henry Bengali film story is about Megh, an psycho author who bagged few prestigious Kolkata Author's Award for her Novel titled 'Henry'. Locket Chatterjee is playing a character of a sexually obsessed author (novelist) who dreams only about doing sex with men. After getting the prestigious award 'Megh' started getting enormous amount of messages & phone calls but she started ignoring all of those calls coming from media persons for interview. But, the call from Journalist Akash, 'Megh' unable to ignore and convinced by Akash for a story. Locket Chatterjee convinced on one condition to make story if Dibyendu Mukherjee is ready to spend time on bed with her. What happens when

Chaiti is a young beautiful woman and wife of newspaper editor Bikramjit. Bikramjit is a workaholic and always stay busy with his editorial works. In spite of being a highly educated woman, Chaiti has nothing to do and she spends her time with expensive saris, filing nails, watching TV. Thus unhappy with her marriage (lack of physical intimacy with her husband) and after an unfortunate miscarriage Chaiti befriends Amal to find a friendly company.

Residents of Calcutta find solace from their hectic daily lives in conversations at one cafe or another. Newton is a member of one such group of cafe regulars. He appears to be in a romantic relationship with Ananya. Newton wants to start a business. Ananya consults her actress friend Laboni, who asks script-writer Arup to help Newton. However, Arup is perhaps too mysterious a character.