An unsuspecting family on a road trip stumbles into a motel on a seedy stretch on historic Route 66. From the outside this looks like any other budget motel, but as the doors slowly open they uncover a world of sin, addiction, pain, longing and desperation from which there is little chance of escape.

Henry Howard, an ambitious young scientist struggles to develop a super human serum designed to improve muscle mass and prolong life expectancy. His boss, the grumpy General Darwin, will not allow Hank to marry his daughter, Hannah, until the experiment is a success. Against Darwin's wishes Hank proposes to Hannah anyway, but his life is shattered by a mugger who steals his engagement ring. Dejected, Hank injects himself with the experimental serum and is transformed into the Amazing Bulk. The Bulk goes on a rampage through the city destroying everything in his path. Hank is caught by a relentless detective, imprisoned by Darwin and forced to battle the sadistic Dr. Kantlove, who threatens to blow up the moon with his arsenal of weapons.

Visions of a past relationship leave Matthew broken and isolated until an intimate encounter at a porn arcade opens a peephole to unexpected possibilities.

Little Taiko Boy's soundtrack is a safer-sex parody of the American Christmas carol "The Little Drummer Boy" interspersed with the slow rumble of a traditional Japanese taiko drum that sounds like a massive throbbing heart beat. Against this backdrop, several men meet in Tokyo's bathhouses, love hotels and cruising spots for intimate encounters, watched over by a glamorous drag version of Amaterasu Omikami, the Shinto goddess of the Sun played by Japanese activist and artist MADAME BONJOUR JOHNJ.