In a desperate search to create a follow-up to Joe Swanberg's 2011 film Uncle Kent, Kent Osborne travels to a comic book convention in San Diego where he loses his mind and confronts the end of the world.

Janie’s just trying to get well. As she recovers from a violent psychotic break, she’s subjected each day to a bizarre holistic health and wellness regimen designed, and enforced, by her lifelong nanny and caretaker. But when she develops an obsession with a stranger, Janie's buried demons begin to surface.