UFC 70 was the second UFC event held in the United Kingdom, and the first in Manchester. The first UFC event in the UK was UFC 38: Brawl at the Hall on July 13, 2002. UFC 70 was also only the seventh UFC event held outside the United States, and the first since UFC 38. 2006 PRIDE Open-Weight Grand Prix Champion, Mirko Cro Cop fought Heavyweight contender Gabriel Gonzaga in the main event to determine the top contender for the UFC Heavyweight Championship held by Randy Couture.

UFC Fight Night 21: Florian vs. Gomi was a mixed martial arts event held by the Ultimate Fighting Championship on March 31, 2010 at Bojangles Coliseum in Charlotte, North Carolina, This was the third time the UFC held an event in Charlotte, but the first since UFC 5.

UFC 122: Marquardt vs. Okami was a mixed martial arts event held by the Ultimate Fighting Championship on November 13, 2010 at König Pilsener Arena in Oberhausen, Germany. Vitor Belfort was set to face Yushin Okami in the main event, with the winner receiving a middleweight title shot. However, on September 21, 2010, Belfort withdrew from the fight to face Anderson Silva. Nate Marquardt ended up fighting Yushin Okami in the main event, which would still determine the next #1 contender.

UFC 132: Cruz vs. Faber was a mixed martial arts event held by the Ultimate Fighting Championship on July 2, 2011 at the MGM Grand Garden Arena in Las Vegas, Nevada.

UFC 127: Penn vs. Fitch was a mixed martial arts event held by the Ultimate Fighting Championship on Sunday, 27 February 2011 at Acer Arena in Sydney, Australia.

UFC 137: Penn vs. Diaz was a mixed martial arts event held by the Ultimate Fighting Championship on October 29, 2011 at Mandalay Bay Events Center in Las Vegas, Nevada.

UFC on Fuel TV 2: Gustafsson vs. Silva was a mixed martial arts event held by the Ultimate Fighting Championship on April 14, 2012 at the Ericsson Globe Arena in Stockholm, Sweden.

UFC 162: Silva vs Weidman was a mixed martial arts event on July 6, 2013 at the MGM Grand Garden Arena in Las Vegas, Nevada.

UFC Fight Night 59: McGregor vs. Siver was a mixed martial arts event held on January 18, 2015, at the TD Garden in Boston, Massachusetts. The event was headlined by a featherweight bout between Conor McGregor and Dennis Siver. It was announced that a victory over Siver will ensure McGregor of a shot at the UFC Featherweight Championship in his next fight.

UFC Fight Night 69: Jedrzejczyk vs. Penne was a mixed martial arts event held on June 20, 2015 at O2 World in Berlin, Germany. A UFC Women's Strawweight Championship bout between current champion Joanna Jędrzejczyk and former Invicta FC Atomweight champion Jessica Penne was announced as the event headliner.