The story centers around Nathaniel Nucci, who leaves the military when his wife becomes pregnant hoping to lead a "normal" life. All is well for 13 years until his wife and child are part of collateral damage on a botched Mafia hit. Blinded by rage, Nathaniel infiltrates the Mafia organization responsible for the murder of his family. He ultimately becomes a contract killer for the head of one of Philadelphia's largest Mafia families, while keeping his identity hidden.

A small town farmer exacts his bloody revenge on unscrupulous town folk who try to steal his land.

Following the events of Sacrum Vindictae II, Nathaniel Nucci is on the run. Facing insurmountable odds, Nucci must confront his past, his mistakes, and his own mortality.