The lives of rival gang members, a teacher, a TV news crew and other intertwine in the city of Los Angeles.

Ladies Night Out is a Jamaican Urban drama about 4 young ladies who came to America a kids and because of unfortunate circumstances were placed into the foster care system. After being abused emotionally, physically and sexually the ladies all grown up now are planning to go out for a night on the town, but unknowing to them all of their traumatic experiences from childhood that they have managed to suppress will resurface on this "Ladies Night Out"