A small-town sheriff in the American West enlists the help of a disabled man, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.

Danny Ocean and his gang attempt to rob the five biggest casinos in Las Vegas in one night.

Ann-Margret starts her journey to Hollywood from the countryside, traversing the Freeway until she gets to Hollywood.

Clips from assorted television programs, B-movies, commercials, music performances, newsreels, bloopers, satirical short films and promotional and government films of the 1950s and 1960s are intercut together to tell a single story of various creatures and societal ills attacking American cities.

When Count Contini attempts to destroy the world's economy by masterminding the theft of $1 billion in U.S. gold, ICE chief MacDonald summons secret agent Matt Helm to stop him.

An airport manager tries to keep his terminals open during a snowstorm, while a suicide bomber plots to blow up a Boeing 707 airliner in flight.

The players in an ongoing poker game are being mysteriously killed off, one by one.

A cross-country road race is based on an actual event, the Cannonball Baker Sea to Shining Sea Memorial Trophy Dash, organized by Brock Yates to protest the 55 mph speed limit then in effect in the U.S. The Cannonball was named for Erwin G. "Cannonball" Baker, who in the roaring 20's rode his motorcycle across the country. Many of the characters are based on ruses developed by real Cannonball racers over the several years that the event was run.

Matt Helm is called out of retirement to stop the evil Big O organization who plan to explode an atomic bomb over Alamagordo, NM, and start WW III.

Rich momma's boy Wade Kingsley Jr. an Eastern dude, tries to follow in his murdered father's footsteps by returning to the West to partner up with Slim Moseley Jr.,the son of his father's former partner. Wade overcomes Slim's initial reluctance to accept him by using his fortune to buy a prize cow and new car to help Slim in his job as foreman on the Kingsley family ranch, currently under siege by a gang of outlaws called "masked raiders." Wade generously tries to pay off the ranch's mortgage with $15,000 of his own money, but unfortunately neither "pardner" realizes that respected banker Dan Hollis, the son of their fathers' murderer, is the leader of the gang.